Improvement in renal function and rejection control in pediatric liver transplant recipients with the introduction of sirolimus
β Scribed by Adela T. Casas-Melley; Kathleen P. Falkenstein; Louise M. Flynn; Valerie L. Ziegler; Stephen P. Dunn
- Book ID
- 110895770
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 82 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1397-3142
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Sirolimus is used in patients with renal insufficiency after liver transplantation (LT) and especially in those with calcineurin inhibitor (CNI)-associated nephrotoxicity. We conducted a systematic review of all randomized controlled trials and observational studies to test the hypothesis that the u
Chronic renal dysfunction is a frequent and severe complication in solid-organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and siro