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Improvement in Neuromuscular transmission in Myasthenia Gravis by 3,4-Diaminopyridine

✍ Scribed by H. Lundh; O. Nilsson; I. Rosén

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
361 KB
Volume
234
Category
Article
ISSN
1433-8491

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✦ Synopsis

3,4-Diaminopyridine ( 3,4-DAP), a potent potentiator of action potential evoked release of acetylcholine from presynaptic terminals in the neuromuscular junction was given i v and p o to two patients with myasthenia gravis. Effects were monitored electrophysiologically by repetitive nerve stimulation and by standardized clinical testing.

Administration of 8 mg and 9 mg 3,4-DAP i v produced a clear improvement in the neuromuscular transmission after approximately 20 min.

When 3,4-DAP was given p o 24 mg was shown to be effective At a dosage of 18-24 mg p o 3,4-DAP significantly potentiated the effect of the cholinesterase inhibitor pyridostigmine at an optimal dose The maximal effect of 3,4-DAP p.o was obtained after 2 5-3 h.

No significant CNS side-effects were found which is in contrast to those reported for 4-aminopyridine.

The results suggest that 3,4-DAP may be useful as an addition to the conventional treatment with cholinesterase inhibitors when immunosuppressive treatment is considered contraindicated or when it has not yet reached its full effect.

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