The potential of cyclodextrins to stabilize a-chymotrypsin upon encapsulation in Poly(lactic-co-glycolic) acid (PLGA) microspheres using a solid-in-oil-in-water (s/o/w) technique was investigated. Two cyclodextrins, hydroxyl-propyl-b-cyclodextrin (HPbCD) and methyl-b-cyclodextrin (MbCD), one insolub
✦ LIBER ✦
Improved α-Chymotrypsin Stability Upon Encapsulation in PLGA Microspheres by Solvent Replacement
✍ Scribed by Ingrid J. Castellanos; Kai Griebenow
- Book ID
- 111603455
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 253 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0724-8741
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The effectiveness of the covalent modification of a-chymotrypsin with methoxy poly(ethylene glycol) (PEG) to afford its stabilization during encapsulation in poly(lactic-co-glycolic) acid (PLGA) microspheres by a solid-in-oil-in-water method was investigated. a-Chymotrypsin was chemically modified w