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Improved techniques for kidney transplantation in the monkey

✍ Scribed by Shijie Qi; Junzheng Peng; Dasheng Xu; Minh Diem Vu; Dingyi Liu; Huifang Chen

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 44 KB
Volume: 19
Category: Article
ISSN: 0738-1085
DOI: 10.1002/(sici)1098-2752(1999)19:7<335::aid-micr9>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

Improved microsurgical techniques for kidney transplantation in the monkey are described. The left graft kidney is transplanted to the lower part of abdomen with end-to-side anastomoses of renal artery to aorta without a patch of aorta, renal vein to inferior vana cava, and end-to-end anastomosis of donor and recipient ureter with 8-0 nylon sutures in a bilateral nephrectomized recipient monkey. We recently performed 60 kidney transplantations in Vervet moneys. None died of surgery or surgical complications. This reproducible model provides a useful tool to test new immunosuppressants and to investigate the mechanism of drug-induced tolerance and xenotransplantation in primates as a support to clinical trial.

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