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Improved synthesis of substituted pyrido[2,3-d]pyrimidinediones

โœ Scribed by Gwydion H. Churchill; Steven A. Raw; Lyn Powell


Book ID
104099267
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
725 KB
Volume
52
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


An improved methodology for the synthesis of substituted pyrido [2,3-d]pyrimidinediones from 6-aminouracils and the corresponding enaminone has been developed which provides high yields via an operationally simple process. The method has been extended to encompass a range of electron-rich enaminones, a substrate class that does not perform well under the standard conditions.


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