Improved synthesis of substituted pyrido[2,3-d]pyrimidinediones
โ Scribed by Gwydion H. Churchill; Steven A. Raw; Lyn Powell
- Book ID
- 104099267
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 725 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
An improved methodology for the synthesis of substituted pyrido [2,3-d]pyrimidinediones from 6-aminouracils and the corresponding enaminone has been developed which provides high yields via an operationally simple process. The method has been extended to encompass a range of electron-rich enaminones, a substrate class that does not perform well under the standard conditions.
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