Improved synthesis of oligonucleoside methylphosphonate analogs
โ Scribed by Ivan Habus; Theresa Devlin; Radhakrishnan P. Iyer; Sudhir Agrwal
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 405 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A P" coupling reagent 3 containing indole group is described. Its usefulness is demonstrated by the synthesis of dinucleoside methylphosphonates and methylthiophosphonates. 8 1997 Elsevier Science Ltd. The oligonucleoside methylphosphonates (MP) show significant potential for antisense therapy.' The
The transamination side product formed by the use of dC bz or dC \*~ methylphosphonamidite upon treatment with ethylenediamine has been eliminated by the use of dC Ac methylphosphonamidite. The synthesis and characterization of DMT dC Ac methylphosphonamidite is described.