Starting from inexpensive polyhydroxybutanoate (PHB), D-allothreonine 1 and L-threonine 2 were synthetized by a sequence involving a diastereoselective electrophilic amination. When (%I 3-hydroxybutanoic acid was protected as dioxanone? very good yield (>95 %I and high diastereomeric excess (>99 %)
β¦ LIBER β¦
Improved synthesis of d-allothreonine derivatives from l-threonine
β Scribed by Kikuchi, Mari; Konno, Hiroyuki
- Book ID
- 120527437
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 313 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Electrophilic amination: Enantioselectiv
β
J.P Genet; S Juge; S Mallart
π
Article
π
1988
π
Elsevier Science
π
French
β 200 KB
Asymmetric synthesis of threonine and al
β
Yu. N. Belokon'; M. M. Dolgaya; N. I. Kuznetsova; S. V. Vitt; V. M. Belikov
π
Article
π
1973
π
Springer
π
English
β 201 KB
Synthesis of glucosaminides of l-threoni
β
V. A. Derevitskaya; E. M. Klimov; N. K. Kochetkov
π
Article
π
1969
π
Springer
π
English
β 190 KB
Synthesis of Allothreonine-Threonine fro
β
Gilbert, James B.
π
Article
π
1957
π
American Chemical Society
π
English
β 503 KB
Synthesis of N-benzoyl-L-daunosamine fro
β
Claudio Fuganti; Piero Grasselli; Giuseppe Pedrocchi-Fantoni
π
Article
π
1981
π
Elsevier Science
π
French
β 188 KB
Synthesis of Ξ΄-(l-Ξ±-aminoadipoyl)-l-cyst
β
SigthΓ³r PΓ©tursson; Jack E Baldwin
π
Article
π
1998
π
Elsevier Science
π
French
β 491 KB
The paper describes the synthesis of two epimeric tdpeptides &(L-cx-aminoadipoyl)-L-cysteinyI-D-(Omethyl)-D-threonine (13) and &(L-ct-aminoadipoyl)-L-cysteinyl-D-(O-methyl)-D-allothreonine ( 14), modified substrates for the isopenicillin-N synthase enzyme. The D-allothreonine tripeptide ( 14) has be