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Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

✍ Scribed by Flaherty, Keith T.; Robert, Caroline; Hersey, Peter; Nathan, Paul; Garbe, Claus; Milhem, Mohammed; Demidov, Lev V.; Hassel, Jessica C.; Rutkowski, Piotr; Mohr, Peter; Dummer, Reinhard; Trefzer, Uwe; Larkin, James M.G.; Utikal, Jochen; Dreno, Brigitte; Nyakas, Marta; Middleton, Mark R.; Becker, Jürgen C.; Casey, Michelle; Sherman, Laurie J.; Wu, Frank S.; Ouellet, Daniele; Martin, Anne-Marie; Patel, Kiran; Schadendorf, Dirk

Book ID
111886683
Publisher
Massachusetts Medical Society
Year
2012
Tongue
English
Weight
157 KB
Volume
367
Category
Article
ISSN
0096-6762

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✍ Flaherty, Keith T.; Infante, Jeffery R.; Daud, Adil; Gonzalez, Rene; Kefford, Ri 📂 Article 📅 2012 🏛 Massachusetts Medical Society 🌐 English ⚖ 528 KB

## Background Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with da braf e nib, a selective BRAF inhibitor, and trametinib, a