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Improved, rapid spectrophotofluorometric method for assay of isoproterenol hydrochloride injections: A comparative study

✍ Scribed by V. K. Prasad; R. A. Ricci; B. C. Nunning; A. P. Granatek

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
711 KB
Volume
62
Category
Article
ISSN
0022-3549

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✦ Synopsis

A spectrophotofluoronietric method for the determination of isoproterenol hydrochloride in parenteral formulations is described. This method is quite simple, precise, and extremely specific for unchanged isoproterenol in decomposed formulations. The method depends on the initial oxidation of isoproterenol hydrochloride with iodine-potassium iodide solution in pH 4.0 (McIlvaine's citrate-phosphate) buffer. The partially oxidized iso-

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