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A rapid and simple HPLC method for the determination of curcumin in rat plasma: assay development, validation and application to a pharmacokinetic study of curcumin liposome

✍ Scribed by Ji Li; Yunyun Jiang; Jun Wen; Guorong Fan; Yutian Wu; Chuan Zhang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
360 KB
Volume
23
Category
Article
ISSN
0269-3879

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## Abstract A simple HPLC method with ultraviolet detection has been developed and validated for the simultaneous determination of haplamine and its metabolites (__trans__/__cis__‐3,4‐dihydroxyhaplamine) in rat. A liquid–liquid extraction was used to extract the compounds from rat plasma. The analy