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Improved pharmacological chaperones for the treatment of neuronopathic Gaucher and Parkinson's disease

✍ Scribed by Sean Clark; Gary Lee; Robert Boyd; Sean Sullivan; Lee Pellegrino; Michelle Frascella; Richie Khanna; Nastry Brignol; Brandon Wustman; Philip Rybczynski; Elfrida Benjamin; Kenneth Valenzano; David J. Lockhart


Book ID
116989136
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
56 KB
Volume
102
Category
Article
ISSN
1096-7192

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✍ Farah Oulaïdi; Sophie Front-Deschamps; Dr. Estelle Gallienne; Dr. Eric Lesellier 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

## Abstract A series of __O__‐alkyl iminoxylitol derivatives was synthesized and evaluated as β‐glucocerebrosidase (GCase) inhibitors. This structure–activity study shows a dramatic influence of the position of the alkyl chain (α‐C1, O2, O3, or O4) on human GCase inhibition. Remarkably, 1,2‐shift o