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Improved multiplicity-editing of HMBC NMR spectra

✍ Scribed by Andrew J. Benie; Ole W. Sørensen

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
200 KB
Volume
44
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

A new improved multiplicity‐edited HMBC experiment is introduced that leads to better J cross‐talk suppression in the even (i.e. C + CH~2~ groups) and odd (i.e. CH + CH~3~ groups) subspectra. By combining data recorded with three different pulse sequences J cross‐talk becomes a second‐order effect in Δ^1^J, i.e. the deviation of an actual ^1^J coupling constant from the value ^1^J~0~ used in setting delays τ = (^1^J~0~)^−1^/2, which is adequate for most applications. As for the original multiplicity‐edited HMBC experiment, the improved experiment can be performed with a single excitation delay or implemented in a broadband version similar to broadband HMBC. Copyright © 2006 John Wiley & Sons, Ltd.

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