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Improved method for morphine extraction from biological samples

✍ Scribed by G. L. Sprague; A. E. Takemori

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
371 KB
Volume
68
Category
Article
ISSN
0022-3549

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✦ Synopsis

0 Methadone, morphine, or naloxone extraction from brain homogenates, plasma, and urine is described. An aqueous sample was loaded on a surgical gauze support, which was washed with extracting solvents. Aqueous samples remained on the support, and nonpolar drugs partitioned into the lipophilic extracting solvent. The procedure recovered 80-100?6 of nanogram levels of methadone, morphine, or naloxone from biological samples. In addition, an approximate 10-fold timesaving capacity was demonstrated compared to standard liquid-liquid extraction techniques.

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