Improved estimate of the Gm-Pi linkage
β Scribed by T. GEDDE-DAHL Jr; P. J. L. COOK; M. K. FAGERHOL; J. A. PIERCES
- Book ID
- 115247352
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 489 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0003-4800
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π SIMILAR VOLUMES
Linkage data of the four gene markers Pi, Gm, GLO, and HLA exclude Gm and Pi gene assignment to the short arm of chromosome 6. The findings, however, do not disprove the following gene order: HLA--GLO--centromere--Gm--Pi.
We conducted linkage analyses of immunoglobulin G heavy chain marker (Gm) phenotypes and multiple sclerosis (MS) in 30 families, each having at least two first-degree relatives with definite/probable MS. These families yielded positive evidence for linkage to human leukocyte antigen (HLA) loci in pr