From family studies close linkage between the gene locus for variegate porphyria (VP) and the alpha-1-antitrypsin (PI) gene became evident. The maximal lod score from male meioses was 4.33 at theta = 0.04 and from both sexes combined 3.56 at theta = 0.12. Three pedigrees were triple informative rega
Linkage studies on the human Pi, Gm, GLO, and HLA genes
✍ Scribed by K. Bender; C. R. Müller; Anita Schmidt; Ulrike Strohmaier; T. F. Wienker
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 260 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
✦ Synopsis
Linkage data of the four gene markers Pi, Gm, GLO, and HLA exclude Gm and Pi gene assignment to the short arm of chromosome 6. The findings, however, do not disprove the following gene order: HLA--GLO--centromere--Gm--Pi.
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