Development of clinical dosage forms for
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Rose-Marie Dannenfelser; Handan He; Yatindra Joshi; Simon Bateman; Abu T.M. Sera
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Article
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2004
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John Wiley and Sons
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English
β 135 KB
π 1 views
Different formulation approaches were evaluated to ensure that the formulation of a poorly water soluble compound chosen during early development achieves optimum bioavailability. The insoluble compound has an aqueous solubility of 0.17 mg/mL at 25 AE 18C, a relatively high permeability (Caco2 P app