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Improved dissolution of a poorly water-soluble drug from solid dispersions in polyethylene glycol: Polysorbate 80 mixtures

✍ Scribed by Abu T. M. Serajuddin; Pai-Chang Sheen; Matthew A. Augustine


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
246 KB
Volume
79
Category
Article
ISSN
0022-3549

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Different formulation approaches were evaluated to ensure that the formulation of a poorly water soluble compound chosen during early development achieves optimum bioavailability. The insoluble compound has an aqueous solubility of 0.17 mg/mL at 25 AE 18C, a relatively high permeability (Caco2 P app