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Improved Cross Peak Detection in Two-Dimensional Proton NMR Spectra Using Excitation Sculpting

✍ Scribed by Que N. Van; A.J. Shaka

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
119 KB
Volume
132
Category
Article
ISSN
1090-7807

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✦ Synopsis

In two-dimensional homonuclear experiments, reliable detection of very small cross peaks is sometimes hampered by t1-noise from larger diagonal peaks which have the same F2 frequency. This t1-noise can be selectively removed by recording partial 2D spectra using the double pulsed field gradient spin echo (DPFGSE). Resonances not selected by the DPFGSE do not contribute any t1-noise to the resulting spectrum. The absence of t1-noise from the diagonal peaks render the small cross peaks at the same F2 frequency observable. The success of this technique is shown by partial 2D NOESY and TOCSY spectra.

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