Improved Chou-Fasman method for protein secondary structure prediction
β Scribed by Hang Chen; Fei Gu; Zhengge Huang
- Book ID
- 115000676
- Publisher
- BioMed Central
- Year
- 2006
- Tongue
- English
- Weight
- 501 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2105
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A novel computerized program has been developed for predicting the secondary structure of proteins from their amino acid sequences. The scheme of the Chou and Fasman method (1978, Adv. Enzymol. Relat. Subj. Biochem. 47,45-148) is closely followed. Some of their qualitative rules have been converted
A new dataset of 396 protein domains is developed and used to evaluate the performance of the protein secondary structure prediction algorithms DSC, PHD, NNSSP, and PREDATOR. The maximum theoretical Q 3 accuracy for combination of these methods is shown to be 78%. A simple consensus prediction on th