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A computerized version of the Chou and Fasman method for predicting the secondary structure of proteins

✍ Scribed by G. Deleage; B. Tinland; B. Roux

Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 443 KB
Volume: 163
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(87)90226-0

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✦ Synopsis

A novel computerized program has been developed for predicting the secondary structure of proteins from their amino acid sequences. The scheme of the Chou and Fasman method (1978, Adv. Enzymol. Relat. Subj. Biochem. 47,45-148) is closely followed. Some of their qualitative rules have been converted to numeric scales to obtain unambiguous predictions. This program has been tested on 2 1 proteins with known three-dimensional structures constituting a 4457 amino acids data base. The percentage of correctly predicted amino acids is between 4 1 and 66% for a three-state (helix, sheet, and coil) description of protein secondary structure. o 1987 Academic Press, Inc.

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