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Improved asymmetric syntheses of (R)-(−)-homocitrate and (2R,3S)-(−)-homoisocitrate, intermediates in the α-aminoadipate pathway of fungi

✍ Scribed by Guoxiang Ma; David R.J Palmer

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 71 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01707-x

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✦ Synopsis

Improved asymmetric syntheses of the title compounds are reported. Both products are produced through diastereoselective alkylation of malic acid; (R)-homocitrate synthesis uses the self-regeneration of stereocenters approach. Both procedures represent an improvement in yield over existing methods without loss of stereoselectivity.

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