## Abstract The titanium derivative 2 of the bislactim ether 1 of cyclo(‐L‐Val‐Gly‐) reacts with aldehydes and ketones 3 highly diastereoselectively to give the __syn__‐addition products 4. Upon hydrolysis with diluted trifluoroacetic acid the compounds 4 yield besides methyl L‐valinate the (2__R__
✦ LIBER ✦
Asymmetric Syntheses via Heterocyclic Intermediates, XLII. Asymmetric Syntheses of Diastereomerically and Enantiomerically Pure (2R,3S)-threo-3-Arylserine Methyl Esters by the Bislactim Ether Method Asymmetric Synthesis of Chloramphenicol
✍ Scribed by Schöllkopf, Ulrich ;Beulshausen, Tessa
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 286 KB
- Volume
- 1989
- Category
- Article
- ISSN
- 0947-3440
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## Abstract A novel method for the synthesis of __N__‐methylserines has been developed. The oxazolidines 4 are formed by condensation of the serine methyl esters 1 with formaldehyde. These intermediates are subsequently reduced to the __N__‐methylserine methyl esters 9 by an acid‐catalyzed ring ope