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Asymmetric Syntheses via Heterocyclic Intermediates, XLII. Asymmetric Syntheses of Diastereomerically and Enantiomerically Pure (2R,3S)-threo-3-Arylserine Methyl Esters by the Bislactim Ether Method Asymmetric Synthesis of Chloramphenicol

✍ Scribed by Schöllkopf, Ulrich ;Beulshausen, Tessa


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
286 KB
Volume
1989
Category
Article
ISSN
0947-3440

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## Abstract A novel method for the synthesis of __N__‐methylserines has been developed. The oxazolidines 4 are formed by condensation of the serine methyl esters 1 with formaldehyde. These intermediates are subsequently reduced to the __N__‐methylserine methyl esters 9 by an acid‐catalyzed ring ope