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Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors

โœ Scribed by DURANT, G. J.; DUNCAN, W. A. M.; GANELLIN, C. R.; PARSONS, M. E.; BLAKEMORE, R. C.; RASMUSSEN, A. C.


Book ID
109711365
Publisher
Nature Publishing Group
Year
1978
Tongue
English
Weight
399 KB
Volume
276
Category
Article
ISSN
0028-0836

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Short-term toxicological studies with im
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## Abstract Impromidine is a specific, potent histamine H~2~โ€receptor agonist. The present paper describes the results of acute and shortโ€term repeatedโ€dose toxicity studies with impromidine in rodents and dogs. The intravenous LD~50~ was 9.6 mg kg^โˆ’1^ in male mice, 12.7 mg kg^โˆ’1^ in female mice an