In this study we examined the regulation of expression of the human MUC1 gene in vivo, by developing MUC1 transgenic mice. The data showed that epithelial-specific expression of MUC1 can be directed by just 1.4 kb of 5' flanking sequence using MUC1 cDNA as a reporter gene in vivo. Furthermore, high
β¦ LIBER β¦
Importance of MUC1 and spontaneous mouse tumor models for understanding the immunobiology of human adenocarcinomas
β Scribed by Olivera J. Finn; Kira R. Gantt; Andrew J. Lepisto; Sharmila Pejawar-Gaddy; Jia Xue; Pamela L. Beatty
- Book ID
- 107572541
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 945 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0257-277X
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## Abstract The neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. One known function of neurofibromin, the NF1 protein product, is to accelerate the slow intrinsic GTPase activity of Ras to increase the production of inactive rasGDP, with wideβranging effects on p21ras pathw