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Importance of genetic predisposition and maternal environment for the occurrence of congenital malformations in offspring of diabetic rats

โœ Scribed by Eriksson, Ulf J.

Book ID
112217837
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
880 KB
Volume
37
Category
Article
ISSN
0040-3709

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## Background: We have previously reported on a malformation-prone Sprague-Dawley rat substrain (U), which presents a high frequency of micrognathia in the offspring of diabetic mothers. This malformation is related to impaired development of the cranial neural crest cells (NCC); the defect may be