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Importance of Chromium−DNA Adducts in Mutagenicity and Toxicity of Chromium(VI)

✍ Scribed by Zhitkovich, Anatoly


Book ID
121076815
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
126 KB
Volume
18
Category
Article
ISSN
0893-228X

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Induction of mutagenic DNA damage by chr
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Certain chromium (Cr) compounds are known to be carcinogenic in humans and mutagenic in cell culture. However, the mechanism of Cr mutagenesis is not well understood. It appears that intracellular reduction of Cr by agents such as glutathione plays a role in the induction of DNA damage. We have used