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Importance of 5-hydroxytryptamine in the antinociceptive activity of the leucine-enkephalin derivative, D-Ala2-Leu5-enkephalin (BW 180C), in the rat

โœ Scribed by R.L. Lee; R.D.E. Sewell; P.S.J. Spencer


Book ID
118322994
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
164 KB
Volume
47
Category
Article
ISSN
0014-2999

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Synthesis of [D-Ala2, D-Leu5]enkephalin
โœ Hiroshi Hasegawa; Yoshihiko Shinohara; Shigeo Baba ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 351 KB

D-Ma2, D-Leu51Enkephalin (DADLE) labelled with tritium in the 2,6-positions of N-terminus tyrosine residue has been prepared. Synthesis of the precursor peptide, [2,6-dibromo-Tyrl]DADLE, was performed by solid phase synthesis using F'moc strategy. The peptide was tritiated catalytically to yield [2