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Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

✍ Scribed by Federico Garrido; Francisco Ruiz-Cabello; Teresa Cabrera; Juan J. Pérez-Villar; Miguel López-Botet; Maggie Duggan-Keen; Peter L. Stern

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
670 KB
Volume
18
Category
Article
ISSN
0167-5699

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✦ Synopsis

HLA class 1 downregulation is a frequent emlt aswiafed with turnour invasion and developtnent. Altered HLA class I tutnorrr plrenoh~pes ten knw projounC etJects on T-cell and natural killer LVIO-cell arztifrrrnolrr responses. Here. Federico Garrido and colleqgaes analyse these altered turxozrr phenotypes in detail, indicating Mr potentid relezmce for implementation of irrmn;lrnoflz~a~tltic protocols and strategies to overconze fwnow escaue mechanr5ms. vaccinia viruses encoding HPV oncogene pmdu&. Any T-ceu-mediated action Is dependent on the expression of ftm&maI and r&writ major hist-patibih!y complex tMHCl c&s I tn&c&s by the tumour targets. Human MHC HLA c'Lis.s I downregulation is a widespread gells~, PS .d is autoIogous or auogeneic tumom cC.3 witi or without lytckim heIf. Similarly, imm~py for cvtvigl carcinoma might be possible using human pap& lomavims (HIV-derived peptides' or live phenwnenon in -ix bto:~~' and probably tegectc tomour es cap-z nechmisms sshcted owing tn the role of HLA molecules nt Iwsenting immunogenic peptido to T cellss. However, such alteratipn in MHC expression might expose the tunwur variants to natu-4 MIIer (NKkeU attack. since these ceIIs can l+se HLA rlass Ideficienl targets. The temgnbion, activation and destruction of a iarget by the preformed NK celIs in the circuIatIon or t&sties requires o.rty a feiv houn.. Such a nn4anIsm might be of special televance

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