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Implication of CYP 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture

✍ Scribed by Sophie Ellouk-Achard; Chantal Martin; Chuong Pham-Huy; Huynh Thien Duc; Marc Thevenin; Hélène Dutertre-Catella; Jean-Michel Warnet; Jean-Roger Claude


Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
339 KB
Volume
71
Category
Article
ISSN
0340-5761

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The influence of cell density and epidermal growth factor (EGF) on the expression and inducibility of cytochrome P450 (CYP) genes of the CYP3A and CYP1A families in adult human hepatocytes in primary culture has been evaluated. Only when cultured at subconfluence and in the presence of EGF did hepat