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Impairment of Leukocyte Trafficking in a Murine Pleuritis Model by IL-4 and IL-10

✍ Scribed by Jay S. Fine; Alberto Rojas-Triana; James V. Jackson; Laura W. Engstrom; Gregory S. Deno; Daniel J. Lundell; Loretta A. Bober


Book ID
111547719
Publisher
Springer
Year
2003
Tongue
English
Weight
271 KB
Volume
27
Category
Article
ISSN
0360-3997

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## Abstract ## Background Interleukin‐4 (IL‐4) plays a crucial role as an inflammatory mediator in allergic asthma via inducing Th2 inflammation and IgE synthesis. To develop an effective therapeutic agent which specifically inhibits production of IL‐4, antisense oligodeoxynucleotides (AS‐ODNs) ag