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Impaired T-cell development in the absence of Vav1 and Itk

✍ Scribed by Julia Raberger; Nicole Boucheron; Shinya Sakaguchi; Josef M. Penninger; Wilfried Ellmeier


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
676 KB
Volume
38
Category
Article
ISSN
0014-2980

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Several findings support the importance of GM1-enriched lipid microdomains of plasma membrane and of Vav, an essential regulator of actin cytoskeletal rearrangement, in the regulation of T cell activation. Moreover, a functional link among lipid microdomains, Vav and the HIV product Nef has been des