𝔖 Bobbio Scriptorium
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Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection

✍ Scribed by Fernández, Mario; Quiroga, Juan Antonio; Martín, Julio; Cotonat, Teresa; Pardo, Margarita; Horisberger, Michel-Andre; Carreño, Vicente

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
215 KB
Volume
51
Category
Article
ISSN
0146-6615

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✦ Synopsis

MxA protein is interferon inducible, and its role as an antiviral mediator is being studied in various viral diseases. Several cytokines, including type I interferons (␣ and ␤), interleukins 2 and 12, and granulocyte, macrophage, and granulocyte-macrophage colony-stimulating factors, were tested for their ability to induce human MxA protein synthesis in peripheral blood mononuclear cells from 15 chronic hepatitis B virus-infected patients and 6 healthy subjects as controls. Constitutive MxA expression was scarce in patients and controls but increased significantly in response to type I interferons. MxA responsiveness to interferon ␣ was diminished significantly in chronic hepatitis B patients, compared with healthy donors (P < 0.05); this effect was more marked in patients with high viremia levels. Interleukins 2 and 12, and none of the colony-stimulating factors tested, induced low, but detectable, MxA protein levels. These results indicate that chronic infection by hepatitis B virus may impair activation of the immune cells and their capacity to respond to type I interferons.

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