Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome
β Scribed by Paola Porcedda; Valentina Turinetto; Erica Lantelme; Enrico Fontanella; Krystyna Chrzanowska; Riccardo Ragona; Mario De Marchi; Domenico Delia; Claudia Giachino
- Book ID
- 116410573
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 482 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1568-7864
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The autosomal recessive genetic disorder, Nijmegen Breakage Syndrome, is characterised by an excessively high risk for the development of lymphatic tumours and an extreme sensitivity towards ionising radiation. The most likely explanation for these characteristics, a deficiency in the repair of DNA
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