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Impaired Antioxidant Defense System of Colonic Tissue and Cancer Development in Dextran Sulfate Sodium-Induced Colitis in Mice

โœ Scribed by Daisuke Korenaga; Fumio Takesue; Kazuaki Kido; Mitsuhiro Yasuda; Sadaaki Inutsuka; Masayuki Honda; Shunichi Nagahama


Book ID
115636546
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
331 KB
Volume
102
Category
Article
ISSN
0022-4804

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P-glycoprotein (P-gp), the product of the multiple drug resistance (mdr) gene, can actively pump toxic drugs out of cells, but its pathophysiologic role is not yet fully understood. In this study, we examined the expression of P-gp in dextran sodium sulfate (DSS)-induced colitis in mice. Eight-week-