Impaired Anti-Viral Immunity Following Syngeneic Bone Marrow Transplant
โ Scribed by S.M. Coomes; C.A. Wilke; B.B. Moore
- Book ID
- 116280929
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 53 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1083-8791
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## Abstract Sublethally irradiated, immunodeficient, C57BL/6 RAGโ2 geneโdeleted recipient mice reconstituted with T cellโdepleted bone marrow (BM) grafts frequently developed diarrhea, lost weight and showed signs of autoimmunity, dying between 4 and 7โweeks after reconstitution. Mice died despite
In ABO mismatched organ or bone marrow transplants recently some cases of acquired immune hemolysis have been reported. It was felt that these life threatening complications were due to immunosuppressive treatment with cyclosporin-A. A case of severe hemolysis following mismatched BMT is reported. H