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Acquired immune haemolysis by anti a 1 antibody following bone marrow transplantation

✍ Scribed by Haas, R. J. ;Rieber, P. ;Helmig, M. ;Strobel, E. ;Belohradsky, B. H. ;Heim, M. U.

Book ID: 104721659
Publisher: Springer-Verlag
Year: 1986
Weight: 255 KB
Volume: 53
Category: Article
ISSN: 1432-0584
DOI: 10.1007/bf00321102

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✦ Synopsis

In ABO mismatched organ or bone marrow transplants recently some cases of acquired immune hemolysis have been reported. It was felt that these life threatening complications were due to immunosuppressive treatment with cyclosporin-A. A case of severe hemolysis following mismatched BMT is reported. Here no cyclosporin-A treatment was given since the bone marrow was T-cell deprived by an E-rosetting technique. Apparently T-cell purging can under these conditions become dangerous.

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