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Impact of visceral involvements and blood cell count abnormalities on survival in adult T-cell leukemia/lymphoma (ATLL)

✍ Scribed by Yumi Takasaki; Masako Iwanaga; Kunihiro Tsukasaki; Miyuki Kusano; Kazuyuki Sugahara; Yasuaki Yamada; Shimeru Kamihira; Shuichi Ikeda; Masao Tomonaga

Book ID
104040321
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
417 KB
Volume
31
Category
Article
ISSN
0145-2126

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✦ Synopsis

Multiple visceral involvements and various blood cell count abnormalities are frequently manifested in adult T-cell leukemia/lymphoma (ATLL) at diagnosis. We evaluated the effects of four visceral involvement (bone marrow (BM), skin, liver, spleen) and six blood cell count abnormalities (anemia, neutrophilia, thrombocytopenia, monocytosis, eosinophilia, basophilia) on the overall survival of 168 ATLL patients. In the aggressive type, BM involvement, skin involvement and monocytosis were significantly poor prognostic factors. Furthermore, concomitant involvement of BM and additional visceral organs worsened the prognosis. These data support that multiple organ involvements represent a poor prognostic factor for ATLL and provide clinical significance for BM examinations.

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