Random suppression of T cells that bear specific T cell receptor Vβ sequences in adult T cell leukemia/lymphoma (ATLL) patients at each clinical stage: Carrier, smoldering, chronic, and acute
✍ Scribed by Ohshima, Koichi; Suzumiya, Junji; Kikuchi, Masahiro; Takeshita, Morishige; Tashiro, Kotaro; Kimura, Nobuhiro
- Book ID
- 102645643
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 654 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Human T cell leukemia virus type I (HTLV-I) is associated with adult T cell leukemia/ lymphoma (ATLL), which is well known as a T cell malignancy. In order to clarify whether HTLV-I plays a role as a virus-encoded superantigen in the neoplastic process, we examined the TCR Vp families in the peripheral blood at four different clinical stages: carrier, smoldering leukemia, chronic leukemia, and acute leukemia. An increased number of CD4 T cells was found in each of the four clinical stages. However, we found neither uniform specific losses nor uniform clonal expansion of particular TCR Vp gene families in any case from the four clinical stages. However, a suppression of the random TCR Vp families was found. Our data did not therefore directly suggest the existence of a common superantigen model of HTLV-I which induces an increase in CD4 T cells. The random suppression in the TCR Vp repertoire is most likely caused by the influence of HTLV-I neoplastic pathogenesis rather than by virus-encoded superantigens. In the patients with acute leukemia, one or two families of the Vp repertoires were very strongly expressed, while in chronic leukemia, no such repertoire of strong expression was observed. The immunological reaction of the hosts might thus be different between the above described groups. D 1996 Wiley-Liss, Inc.