Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation

✍ Scribed by Michael L. Gatza; Chandtip Chandhasin; Razvan I. Ducu; Susan J. Marriott

• Book ID: 102191075
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 315 KB
• Volume: 45
• Category: Article
• ISSN: 0893-6692
• DOI: 10.1002/em.20088

✦ Synopsis

Abstract

It is estimated that 15% of all cancers are etiologically linked to viral infection. Specific cancers including adult T‐cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human T‐cell leukemia virus type I, hepatitis B virus, and high‐risk human papilloma virus, respectively. In these cancers, genomic instability, a hallmark of multistep cancers, has been explicitly linked to the expression of oncoproteins encoded by these viruses. This review discusses mechanisms utilized by these viral oncoproteins, Tax, HBx, and E6/E7, to mediate genomic instability and cellular transformation. Environ. Mol. Mutagen., 2005. © 2005 Wiley‐Liss, Inc.