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Impact of molecular biology on our understanding of non-Hodgkin lymphoma

โœ Scribed by Brada, M.

Book ID
122747923
Publisher
Elsevier Science
Year
1991
Weight
982 KB
Volume
27
Category
Article
ISSN
0277-5379

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## Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they