𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation

✍ Scribed by Parag Kolhe; Elizabeth Amend; Satish K. Singh


Book ID
102774358
Publisher
American Institute of Chemical Engineers
Year
2009
Tongue
English
Weight
732 KB
Volume
26
Category
Article
ISSN
8756-7938

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Effects of solution conditions, processi
✍ Lisa A. Kueltzo; Wei Wang; Theodore W. Randolph; John F. Carpenter πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 178 KB

Freeze-thawing is a potentially damaging stress to which therapeutic proteins can be exposed deliberately during storage of bulk drug substance, and accidentally because of mishandling of commercial product during shipping and/or storage. The primary route of degradation induced by freeze-thawing is

Comparative effects of pH and ionic stre
✍ Erinc Sahin; Adeola O. Grillo; Melissa D. Perkins; Christopher J. Roberts πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 418 KB

Changes in protein-protein interactions, protein unfolding, and nonnative aggregation were assessed for a series of human IgG1 antibodies as a function of pH and solution ionic strength (I). Unfolding transitions were characterized with differential scanning calorimetry. Protein-protein interactions