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Impact of caspase activation in human spermatozoa

✍ Scribed by Sonja Grunewald; Rakesh Sharma; Uwe Paasch; Hans-Juergen Glander; Ashok Agarwal

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
200 KB
Volume
72
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

Caspases are central components in the apoptosis signaling cascade. The family of cysteine proteases transduces and enhances the apoptosis signal, and activation of effector caspases results in controlled cellular degradation. Although initially the presence of caspases in spermatozoa was controversially discussed in recent years, many studies demonstrated their activation in male germ cells. Activated apoptosis signaling results in decreased fertilizing capacity of the sperm. This review presents the current knowledge on the role of caspases in human sperm. Techniques of caspase monitoring are highlighted. With regard to the high impact of caspases on the sperm fertilizing potential, physiological and pathological settings of caspase activation and inactivation are discussed. Finally, the effects of depletion of caspase‐positive sperm are shown with various standard and molecular sperm preparation methods. Microsc. Res. Tech., 2009. Β© 2009 Wiley‐Liss, Inc.

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## Abstract Caspases are cysteine proteases that play a critical role in the initiation and regulation of apoptosis. These enzymes act in a cascade to promote cell death through proteolytic cleavage of intracellular proteins. Since activation of apoptosis is implicated in human diseases such as can