✦ LIBER ✦

Impact of average weekly dose of radiation during radiotherapy alone or chemoradiotherapy in head and neck cancer

✍ Scribed by Aleksandar F. Dragovic; James A. Bonner; Sharon A. Spencer; Lisle M. Nabell; William R. Carroll; Jimmy J. Caudell

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 196 KB
Volume: 33
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21634

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Altered fractionated radiotherapy (RT) has been shown to improve locoregional control (LRC) and overall survival (OS) in squamous cell cancer of the head and neck (SCCHN). We investigated patient outcomes using a new parameter: the average weekly dose (AWD).

Methods

The medical records of 601 patients who received definitive RT for SCCHN were reviewed. AWD was calculated by dividing the total dose in Gray (Gy) by overall treatment time in weeks, and assessed for predictive value.

Results

Various standard RT fractionation schedules were used. An AWD >10.0 Gy was associated with improved LRC at 2 years for patients treated with RT alone (80.9% vs 60.9%; p = .006), but not for those treated with concurrent chemoradiation (75.3% vs 77.3%; p = .77). Nonsignificant increases in late dysphagia were seen with AWD >10.0 Gy.

Conclusion

An AWD of >10 Gy was found to be beneficial for RT alone regimens but not chemoradiotherapy regimens. Head Neck, 2011

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