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Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells

✍ Scribed by Kathleen G Lanzer,Lawrence L Johnson,David L Woodland…

Book ID: 126376934
Publisher: BioMed Central
Year: 2014
Tongue: English
Weight: 964 KB
Volume: 11
Category: Article
ISSN: 1742-4933
DOI: 10.1186/1742-4933-11-9

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## Abstract Activation of mature CD8^+^ T cells requires recognition, __via__ the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteri