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Immunosuppressive ent-Kaurene Diterpenoids from Isodon serra

✍ Scribed by Ai-Hua Zhao; Yan Zhang; Zhao-Hui Xu; Jian-Wen Liu; Wei Jia

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
101 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Three new enmein‐type ent‐kaurenoids, i.e., the two pairs 1 and 2 of 20‐epimers and the (20__R__)‐isomer 3, besides the seven known diterpenoids 4–10, were isolated from the aerial parts of Isodon serra. Their structures were elucidated by spectroscopic techniques and X‐ray diffraction. The immunosuppressive effect for T‐lymphocytes proliferation induced by Con A in BALB/c mouse was evaluated for the isolates 1–10. They all displayed a remarkable inhibitory effect, with multi‐glycosides of Tripterygium wilfordii as positive reference substance (Table 3).

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