ent-Kaurane Diterpenoids from Isodon phyllostachys

✍ Scribed by Xian Li; Zhi-Ying Weng; Yong Li; Jian-Xin Pu; Sheng-Xiong Huang; Wei-Lie Xiao; Han-Dong Sun

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: German
• Weight: 183 KB
• Volume: 91
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200890121

✦ Synopsis

Abstract

Phytochemical investigation of the medicinal plant Isodon phyllostachys led to the isolation of four new ent‐kaurane diterpenoids, phyllostacins F–I (1–4, resp.), together with 11 known compounds, rosthorin A (5), rabdoternin C (6), enmenol (7), oridonin (8), lasiocarpanin (9), xerophilusin B (10), ponicidin (11), macrocalin B (12), phyllostachysin A (13), sculponeatin C (14), and macrocalyxoformin E (15). The structures of the new compounds were established by spectroscopic methods, including extensive 1D‐ and 2D‐NMR analyses. Compounds 1, 2, 7, 10, and 13 were evaluated for their inhibitory activity against K562 and HepG2 cell lines.