✦ LIBER ✦

Immunosuppression in liver transplantation: Beyond calcineurin inhibitors

✍ Scribed by John Fung; Dympna Kelly; Zakiyah Kadry; Kusum Patel-Tom; Bijan Eghtesad

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 156 KB
Volume: 11
Category: Article
ISSN: 1527-6465
DOI: 10.1002/lt.20373

No coin nor oath required. For personal study only.

✦ Synopsis

Although calcineurin inhibitors (CNIs) remain the mainstay of immunosuppression in liver transplantation (LTX), their long-term toxicity significantly contributes to morbidity and mortality. The elucidation of mechanisms of alloimmunity and leukocyte migration have provided novel targets for immunosuppression development. The toxicities of these agents differ from that of the CNI and act additively or synergistically. CNI avoidance protocols in LTX have not been achieved routinely; however, pilot trials have begun to delineate the limitations and promises of such approaches. CNI-sparing protocols appear to be much more promising in balancing the early need for minimizing rejection while tapering doses and minimizing long-term toxicity.

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