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IMMUNOSTIMULATORY CPG-DNA AND PSA-PEPTIDE VACCINATION ELICITS PROFOUND CYTOTOXIC T CELL RESPONSES

✍ Scribed by Maurer, Tobias; Aguilar-Pimentel, Antonio Juan; Pournaras, Christos; Thalgott, Mark; Heit, Antje; Gschwend, Juergen E; Kuebler, Hubert; Nawroth, Roman


Book ID
122869644
Publisher
Lippincott Williams and Wilkins
Year
2009
Tongue
English
Weight
49 KB
Volume
181
Category
Article
ISSN
0022-5347

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Receptors for conserved molecular patterns associated with microbial pathogens induce synthesis of co-stimulatory molecules and cytokines in immature dendritic cells (DC), as do antigen-reactive CD4 T helper cells via CD40 signaling. Once activated, antigen-presenting DC may activate CD8 T cell resp