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Immunoregulatory properties of CD44+ cancer stem-like cells in squamous cell carcinoma of the head and neck

✍ Scribed by Kazuaki Chikamatsu; Goro Takahashi; Koichi Sakakura; Soldano Ferrone; Keisuke Masuyama

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 599 KB
Volume: 33
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21420

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✦ Synopsis

Abstract

Background

CD44 was found as a surface marker in cancer stem cell (CSC) of squamous cell carcinoma of the head and neck (SCCHN); however, the immunologic properties of such CSCs have not yet been elucidated.

Methods

The immunologic properties of CD44+ cancer stem‐like cells were compared with those of CD44‐ cells using flow cytometry and enzyme‐linked immunosorbent assay.

Results

CD44+ cells exhibited weak HLA‐A2 and class II expression. Interestingly, downregulation of transporter antigen processing (TAP)2 was found in CD44+ cells. The CD44+ cell population produced significantly higher levels of interleukin (IL)‐8, granulocyte colony‐stimulating factor (G‐CSF), and transforming growth factor (TGF)‐β than the CD44‐ cell population. Moreover, CD44+ cells have been shown to not only more strongly inhibit T‐cell proliferation, but also to more efficiently inhibit regulatory T cells (Treg cells) and myeloid‐derived suppressor cells (MDSC) as compared with CD44‐ cells. Additionally, CD44+ cells suppressed Th1 responses and enhanced regulatory T cell responses.

Conclusion

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