Mutations affecting NPM, FLT3 ITD and TKD were present in 25% (30/120), 22% (26/120) and 8/120 (7%), respectively. NPM mutations were most prevalent in patients with normal karyotype (24/52; 46%) and were associated with FLT3-ITD mutations (16/26; 62%). Regarding the prognostic significance of NPM a
β¦ LIBER β¦
Immunophenotypic features of acute myeloid leukaemia patients exhibiting high FLT3 expression not associated with mutations
β Scribed by Roberta Riccioni; Elvira Pelosi; Viviana Riti; Germana Castelli; Francesco Lo-Coco; Ugo Testa
- Book ID
- 108677159
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 307 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0007-1048
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## Abstract In this study, we analysed the prognostic relevance of foetal liver tyrosine kinase 3 (FLT3) mutations in 73 patients with acute myeloid leukaemia (AML) with normal karyotype, who survived induction and consolidation and received autologous stem cell transplantation (ASCT) after success