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Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases

✍ Scribed by Luciano Adorini

Book ID
117798029
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
134 KB
Volume
2
Category
Article
ISSN
1567-5769

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## Abstract Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] induces DCs with a tolerogenic phenotype, characterized by decreased expression of CD40, CD80, and CD86 costimulatory molecules, low IL‐12 and enhanced IL‐10 secretion